Wang H, Xue W, Ouyang W, Jiang X, Jiang X. J Cancer. 2003;15:1015–1024. COVID-19 is an emerging, rapidly evolving situation. Introduction. Loss of nuclear expression may serve as an independent prognostic marker for early-stage oral cancer patients at high risk of recurrence. Kaplan – Meier curve of disease - free survival as a function of…, National Library of Medicine Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. 1. Careers. Asian Pac J Cancer Prev. a) Kaplan –Meier curve of overall survival at five years in patients with OSCC (52.1%); b) Overall survival as a function of GLUT1 staining pattern (, Kaplan – Meier curve of disease - free survival as a function of GLUT3 staining pattern (. 8600 Rockville Pike 2017 Sep;45(9):1464-1471. doi: 10.1016/j.jcms.2017.04.012. Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma. We associated clinical-pathological features of 142 OSCC with the expression pattern of GLUT1 and GLUT3 in order to estimate their prognostic value. Epub 2010 Dec 23. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. Cancer Res. …. Recent research suggests that cancer stem cells (CSC) hold the key to … Immunhistochemical expression of GLUT1 is associated with low grade and low stage of urinary bladder cancer. doi: 10.1002/(SICI)1097-0142(19980701)83:1<34::AID-CNCR5>, Kunkel M., Reichert T.E., Benz P., Lehr H.A., Jeong J.H., Wieand S., Bartenstein P., Wagner W., Whiteside T.L. In clinical practice, the main goal is to give the patient the treatment needed to cure the disease, but at the Privacy, Help GLUT 1 was over expressed in 50.3% of OSSC cases showing membrane staining pattern. Epub 2020 Jun 10. We performed a systematic review to investigate the prognostic significance of the immune checkpoints in OSCC. Squamous intraepithelial neoplasia, non- staining of basal layer. FOIA See this image and copyright information in PMC. Tumorous and adjacent tissues were collected from … 2018 Jul 27;19(7):1779-1783. doi: 10.22034/APJCP.2018.19.7.1779. Shin M, Matsuo K, Tada T, Fukushima H, Furuta H, Ozeki S, Kadowaki T, Yamamoto K, Okamoto M, Jimi E. Carcinogenesis. bone invasion; oral cavity and oropharynx; perineural invasion; squamous cell carcinoma. There is a possibility of local or regional metastasis, which can involve the lymph nodes. GLUT1,…, A) Keratinizing squamous carcinoma. Author information: Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo. A) Keratinizing squamous carcinoma. Prognostic factors aid in the stratification and treatment of cancer. Tumor markers of increased proliferation in oral carcinoma have been identified and explored for more than a decade now. The progression of OPMD to OSCC is a multistep process that provides an opportunity for early cancer detection and interception. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. (2015) 15:743. doi: 10.1186/s12885-015-1727-6. 2002;112:393–396. TROP2 overexpression was detectable in 58% of the tumor samples, indicating it to be a potential novel therapeutic target in squamous cell carcinoma of the oral cavity. MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma. Immunohistochemical analysis of marker expression … eCollection 2020. doi: 10.1002/cncr.11159. Expression of Glut-1 and Glut-3 in untreated oral squamous cell carcinoma compared with FDG accumulation in a PET study. Ying Liu, Department of Stomatology, North Sichuan Medical College, Affiliated Hospital of North Sichuan Medical College, Nanchong, China. Four pairs of tumor and adjacent normal tissues were collected from OSCC patients, and differentially expressed genes (DEGs) were screened via high-throughput RNA sequencing (RNA-seq). eCollection 2020. Genome wide profiling in oral squamous cell carcinoma identifies a four genetic marker signature of prognostic significance Vui King Vincent-Chong, Iman Salahshourifar, The objective of the study was to examine the prognostic value of hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase-IX (CA-IX), cyclooxygenase-2 (COX-2), Ki-67, and erythropoietin receptor in patients with oral tongue squamous cell carcinoma. Asian Pac J Cancer Prev. GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells. Tian M, Zhang H, Nakasone Y, Mogi K, Endo K. Eur J Nucl Med Mol Imaging. The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Would you like email updates of new search results? Immunohistochemical Evaluation of Glucose Transporter Type 1 in Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Grimm M, Munz A, Teriete P, Nadtotschi T, Reinert S. Oral Surg Oral Med Oral Pathol Oral Radiol. Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Several biological and molecular criteria have been established for making a prognosis of OSCC. 1989;49:3759–3764. These results demonstrate that TROP2 overexpression is an independent prognostic marker in patients with oral squamous cell carcinoma. Prognostic biomarkers in oral squamous cell carcinoma: A systematic review. The overall 5-year survival rate following treatment for oral squamous cell carcinoma is around 50% in most published series. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Would you like email updates of new search results? Bone resorption by osteoclasts is an important step in the process of bone invasion by oral SCCs. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Oral Oncol, 49(9):923-931, 17 Apr 2013 Cited by: 53 articles | PMID: 23602254 2011 Nov;32(11):1634-40. doi: 10.1093/carcin/bgr198. 2013 Feb;49(2):119-28. doi: 10.1016/j.oraloncology.2012.08.004. Author information: (1)Department of Stomatology, Children's Hospital of Nanjing Medical University, Nanjing, China. Multidisciplinary Digital Publishing Institute (MDPI). -, Reisser C., Eichhorn K., Herold-Mende C., Born A.I., Bannasch P. Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck. GLUT 1 Glucose transporter Expression in colorectal carcinoma: a marker for poor prognosis. 2021 Feb 28;13(5):1011. doi: 10.3390/cancers13051011. 2020 Oct;26(4):2381-2389. doi: 10.1007/s12253-020-00826-y. Kallinowski F., Schlenger K.H., Runkel S., Kloes M., Stohrer M., Okunieff P., Vaupel P. Blood flow, metabolism, cellular microenvironment and growth rate of human tumor xenography. In the absence of squamous differentiation/keratinization: GLUT1 displays an antistromal pattern, suggestive of hipoxia-driven GLUT1 induction. doi: 10.1097/00005537-200202000-00034. We aimed to identify new biomarkers or potential therapeutic targets for OSCC. A) GLUT1 membrane immunostaining in oral squamous cell carcinoma, 400×; B) GLUT1 expression in oral squamous cell carcinoma. As the morbidity and mortality of the disease have increased year by year, the search for a promising diagnostic and prognostic biomarker for the disease is becoming increasingly urgent. Results: Hence, this study investigated a battery of molecular markers that may help to reflect biologic aggressiveness and predict prognosis. Note also GLUT3 expression in the inflammatory cells, 200×. Axl Is a Prognostic Marker in Oral Squamous Cell Carcinoma. Suwabe Y, Nakano R, Namba S, Yachiku N, Kuji M, Sugimura M, Kitanaka N, Kitanaka T, Konno T, Sugiya H, Nakayama T. PLoS One. Medicine (Baltimore). Oral Surg Oral Med Oral Pathol Oral Radiol. One possible explanation for this is the formation of microenvironment in the perineural space which may contain cellular factors that act on both nerve tissue and some types of tumor tissues. Please enable it to take advantage of the complete set of features! Objectives . Introduction. Note both GLUT1 expression: membrane and nucleus (arrows), 200×; C) GLUT3 membrane immunostaining in oral squamous cell carcinoma; D) No GLUT3 immunostaining. A) GLUT1 membrane immunostaining in oral squamous cell carcinoma, 400×; B) GLUT1 expression…, A) Keratinizing squamous carcinoma. Oral squamous cell carcinoma (OSCC) constitutes a large subgroup of head and neck squamous cell carcinoma and occupies more than 90% of … Cancer. Oral squamous cell carcinoma (OSCC) occasionally occurs in young patients and is likely to be distinct from OSCC in older patients. Mei T, Wang Z, Wu J, Liu X, Tao W, Wang S, Chen F. Biomed Res Int. NCI CPTC Antibody Characterization Program. Oral Oncol. Note positivity at periphery of…, a) Kaplan –Meier curve of overall survival at five years in patients with…, Kaplan–Meier curve of recurrence-free survival…. Oral SCCs provide a suitable microenvironment for osteoclastogenesis to regulate the balance of RANKL and OPG. 2020 Feb 10;11(9):2529-2539. doi: 10.7150/jca.30995. In this thesis we have focused on possible prognostic markers in human oral squamous cell carcinomas, and correlated immunohistochemical staining of putative marker proteins with clinical information to evaluate the prognostic impact. In this retrospective study, we described the clinicopathologic features and outcome of 150 OSCCs that were diagnosed in patients 40-year-old or younger. PubMed Google Scholar 2019 Aug 1;12(8):3049-3057. eCollection 2019. Author information: (1)Jaipur Dental College and Hospital, Jaipur, India (University Affiliation: Maharaj Vinayak Global University, Jaipur, India). doi: 10.1371/journal.pone.0243859. GLUT1, prostromal staining pattern. Background: Oral squamous cell carcinoma (OSCC) is usually preceded by clinically visible changes on oral mucosa categorized as oral potentially malignant disorders (OPMD). GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells. 12. Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Conclusion: 2016 Nov;95(45):e5324. A tissue microarray (TMA) was built for the immunohistochemical (IHC) analysis of GLUT 1 and GLUT 3. D) and E) Basal staning pattern with the superficial layers showing little or no GLUT1 staining in the normal epithelium; F) GLUT1 immunostain (arrow). GLUT1, prostromal staining pattern. Aberrant expression of beta- and gamma-catenin is an independent prognostic marker in oral squamous cell carcinoma Int J Oral Maxillofac Surg , 35 ( 2006 ) , pp. Over expression of GLUT 1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Nevertheless, the prognosis of Squamous Cell Carcinoma of Oral Cavity depends upon many factors including the stage of the tumor and health status of the affected individual. Junction plakoglobin, a potential prognostic marker of oral squamous cell carcinoma, promotes proliferation, migration and invasion. -, Baer S., Casaubon L., Schwartz M.R., Macrogliese A., Younes M. GLUT 3 expression in biopsy specimens of laryngeal carcinoma is associated with poor survival. POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma. J Craniomaxillofac Surg. Prevention and treatment information (HHS). Oral SCCs invade the mandibular or maxillary bone through an erosive, infiltrative or mixed pattern that correlates with clinical behavior. Please enable it to take advantage of the complete set of features! Cancer. Epub 2003 Oct 10. 2021 Feb 4;16(2):e0243859. Involvement of GLUT1 and GLUT3 in the growth of canine melanoma cells. This site needs JavaScript to work properly. Gibo T, Yamada SI, Kawamoto M, Uehara T, Kurita H. Pathol Oncol Res. BMC Cancer. Bethesda, MD 20894, Copyright 1 … 2011 Jul;17(5):462-8. doi: 10.1111/j.1601-0825.2010.01781.x. 1999;80:194–198. GLUT 3 over expression was detected in 21.1% of OSCC cases. Epub 2011 Sep 1. J. Keywords: Cytogenetic significance of chromosome 17 aberrations and P53 gene mutations as prognostic markers in oral squamous cell carcinoma. Oral squamous cell carcinoma (OSCC) has always been one of the most aggressive and invasive cancers among oral and maxillofacial malignancies. Laryngoscope. Clipboard, Search History, and several other advanced features are temporarily unavailable. Zhang X, Junior CR, Liu M, Li F, D'Silva NJ, Kirkwood KL. Bone invasion by oral squamous cell carcinoma: Molecular alterations leading to osteoclastogenesis - a review of literature. PubMed Abstract | CrossRef Full Text | Google Scholar The role of novel prognostic markers PROX1 and FOXC2 in carcinogenesis of oral squamous cell carcinoma. The major prognostic factors are stage at the time of diagnosis, unexpected close margins at resection, depth and pattern of tissue invasion by carcinoma and extracapsular spread. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. National Library of Medicine Accessibility Prognostic significance of human trophoblast cell-surface antigen TROP2 overexpression in 90 patients with oral squamous cell carcinoma regarding overall survival by Kaplan–Meier analysis. Note positivity at periphery of tumour nest, in non-keratinizing basaloid cells, and loss of GLUT1 expression accompanying keratinization at the centre of tumour nest, 200×; B) 400×; C) Non - keratinizing poorly differentiated carcinoma, 100×. Oliveira T, Goldhardt T, Edelmann M, Rogge T, Rauch K, Kyuchukov ND, Menck K, Bleckman A, Kalucka J, Khan S, Gaedcke J, Haubrock M, Beissbarth T, Bohnenberger H, Planque M, Fendt SM, Ackermann L, Ghadimi M, Conradi LC. Histopathology 72 , 905–913 (2018). POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma. Zedan W (1), Mourad MI (2), El-Aziz SM (3), Salamaa NM (4), Shalaby AA (5). Cancer. Bone invasion by OSCC has major implications for tumor staging, choice of treatment, outcome and quality of life. A decreased peritumoral CD1a+ cell number predicts a worse prognosis in oral squamous cell carcinoma. eCollection 2021. Agnihotri NS(1), Astekar M(2). FOIA Despite the importance of immune checkpoints in immunotherapy, the prognostic value of these molecules remains controversial in oral squamous cell carcinoma (OSCC). Most patients (63%) were non-smokers. Tada T, Jimi E, Okamoto M, Ozeki S, Okabe K. Int J Cancer. Profiles of infiltrating immune cells and clinicopathological data were available for 78 OSCC patients with a median follow-up of 48 months. Privacy, Help Bethesda, MD 20894, Copyright 1998;17:34–40. 2004 Jan;31(1):5-12. doi: 10.1007/s00259-003-1316-9. 2016;17(1):147-51. doi: 10.7314/apjcp.2016.17.1.147. Our results suggest that LAMP3 might act as a potential anticancer target and a prognostic marker in patients with OSCC. Int J Clin Exp Pathol. Methods: A more aggressive treatment modality and intensive follow-up may be recommended for the patients with reduced expression of in … The pattern of GLUT 1 expression showed significant association with alcohol consumption (p = 0.004). Accessibility Oral Dis. 2005 Aug 20;116(2):253-62. doi: 10.1002/ijc.21008. It has been concluded that a large number of molecular markers are associated with occurrence, progression, and prognosis of squamous cell carcinoma. Pereira KM, Feitosa SG, Lima AT, Luna EC, Cavalcante RB, de Lima KC, Chaves FN, Costa FW. Some cytokines (e.g. Haoran Ma 1*, Lijuan Li 1*, Lizhou Jia 2, Aixiu Gong 1, Aitao Wang 3, Lingli Zhang 4, … Positive expression of GLUT 3 was associated with unfavorable free-disease survival (p = 0.021). Unable to load your collection due to an error, Unable to load your delegates due to an error. Clinical-pathological features and overall survival data of 142 patients with Oral Squamous Cell Carcinoma (OSCC) were retrospectively reviewed from A.C.Camargo hospital records. 356 - 361 Article Download PDF View Record in Scopus Google Scholar Oral squamous cell carcinoma (SCC), a common malignancy occurring in the oral and maxillofacial region, has high potential for invasiveness and is thus associated with a high mortality rate.1 Distant organ metastasis and regional lymph node metastasis are the major causes of mortality due to oral SCC. Unable to load your collection due to an error, Unable to load your delegates due to an error. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. 2014. This study evaluated prognostic importance of tumor infiltrating immune cell in patients with oral squamous cell carcinoma. A more molecular-based clinical staging and tailor-made therapy would benefit patients with bone invasion by OSCC. Epub 2017 Apr 27. Oral cancer is a subset of head and neck cancers, which originates in the oral cavity [].At least 90% of oral cancers originate from squamous cells and are accordingly designated as oral squamous cell carcinoma (OSCC) [].Despite continuous advances in treatment strategies and diagnostic methods, the incidence and mortality rates associated with OSCC are increasing [3, 4]. Tu XP, Qiu QH, Chen LS, Luo XN, Lu ZM, Zhang SY, et al. Oral squamous cell carcinoma cells induce osteoclast differentiation by suppression of osteoprotegerin expression in osteoblasts. Epub 2012 Sep 16. Careers. Immunohistochemical Investigation of Predictive Biomarkers for Mandibular Bone Invasion in Oral Squamous Cell Carcinoma. Prognostic value of GLUT-1 expression in oral squamous cell carcinoma: A prisma-compliant meta-analysis. 8600 Rockville Pike The cellular and molecular mechanisms of bone invasion by oral squamous cell carcinoma. 2020 Aug 29;2020:1682352. doi: 10.1155/2020/1682352. Positive cell membrane GLUT 3 protein expression was associated with advanced clinic-staging of tumours (p = 0.005) as well as with vascular embolization (p = 0.005). One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Feitosa SG, Viana KF, Luna ECM, Costa FWG, Cavalcante RB, Chaves FN, Chaves HV, Pereira KMA. 2014 Jun;117(6):743-53. doi: 10.1016/j.oooo.2014.02.007. GLUT-1(+)/TKTL1(+) coexpression predicts poor outcome in oral squamous cell carcinoma. Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma. Cancers (Basel). doi: 10.1097/MD.0000000000005324. Oral squamous cell carcinoma (OSCC) is a major type of head and neck cancer, accounting for ~2%–4% of all incident cancer cases per year. IHC results were evaluated according to the staining pattern and number of positive cells. Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma Jaroslav Michalek a , Svetlana Brychtova a , Richard Pink b , Zdenek Dvorak c a Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic However, nuclear expression was observed in 49.7% of the analyzed cases. TNFα and PTHrP) lead to receptor activator of NF-κB ligand (RANKL) expression or osteoprotegerin (OPG) suppression in oral SCC cells and in cancer stromal cells to induce osteoclastogenesis. Kaplan–Meier curve of recurrence-free survival in 5 year in OSCC (64.8%). Epub 2014 Feb 22. Prevention and treatment information (HHS). -. Oral squamous cell carcinoma (OSCC) is the most common oral cancer and has a poor prognosis. Materials and Methods . Ma H (1), Li L (1), Jia L (2), Gong A (1), Wang A (3), Zhang L (4), Gu M (5), Tang G (1). miR-23a-3p/SIX1 regulates glucose uptake and proliferation through GLUT3 in head and neck squamous cell carcinomas. Clipboard, Search History, and several other advanced features are temporarily unavailable. Int. COVID-19 is an emerging, rapidly evolving situation. Chang CC, Yang YJ, Li YJ, Chen ST, Lin BR, Wu TS, Lin SK, Kuo MY, Tan CT. Immunohistochemical Evaluation of GLUT-3 and GLUT-4 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Oral squamous cell carcinoma (OSCC), the most common type of head and neck cancers, is associated with high recurrence, metastasis, low long-term survival rates and poor treatment outcome. This site needs JavaScript to work properly. doi: 10.1002/(SICI)1097-0215(19990118)80:2<194::AID-IJC6>, Haber R.S., Rathan A., Weiser K.R., Pritsker A., Itzkowitz S.H., Bodian C., Slater G., Weiss A., Burstein D.E. Several biological and molecular criteria have been established for making a prognosis of OSCC. Jimi E, Furuta H, Matsuo K, Tominaga K, Takahashi T, Nakanishi O.

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