Collecting duct carcinoma is positive for pancytokeratins (AE1/AE3) and high-molecular-weight cytokeratin, EMA, vimentin, and Ulex europaeus lectin (Table 9).PAX2 and PAX8 (more specific than PAX2) may be positive, as well. Histomorphologic, immunohistochemic and also moleculargenetic characterization can lead to the correct diagnosis and may help to distinguish Bellini duct carcinoma … John P Higgins MD A l'échographie, il n'existe pas de caractéristique tumorale particulière. annaorsola@hotmail.com Am J Surg Pathol. Kobayashi N, Matsuzaki O, Shirai S, Aoki I, Yao M, Nagashima Y. Bellini duct carcinomas have recently been identified as a new entity in the spectrum of renal cell carcinomas and 10 cases have now been reported. Stanford CA 94305-5342, Original posting/last update: 1/24/11, 11/2/16, Metastatic adenocarcinoma must be ruled out clinically and by immunohistochemistry when possible, Bellini duct carcinoma is a very rare type of renal cell carcinoma (RCC), accounting for less than 1%. Digital Atlas of Breast Pathology ; Pathology Outlines - Breast Nonmalignant ; Pathology Outlines - Breast Malignant ... Lobular carcinoma (a pitfall) may appear to be a stromal problem, i.e. Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma. Clearly overlaps morphologically and immunophenotypically with medullary carcinomabut the latter has a distinctive clinicopathologic setting December 2015 Lobular Carcinoma-in-situ 20 slides. IARC Press: Lyon 2016. It is the most common type of breast cancer (70 - 80 %). Our patient presented with a left flank pain evolving for one month a… Its morphological features are extremely variable, making its diagnosis difficult. IHC : CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve //--> Bellini duct carcinomas have recently been identified as a new entity in the spectrum of renal cell carcinomas and 10 cases have now been reported. The oncocytic subtype of IPMT is now known to be genetically separate from other types. We report here a case of CDC with extensive geographic coagulative necrosis mimicking anemic infarct with tumor cells embedded around the necrotic foci in a 73-years-old man. These findings supported our conclusion that the tumor might have originated from the Bellini duct epithelium. Srigley JR, Delahunt B. ICD-10 online (WHO-Version 2019) Das Ductus-Bellini-Karzinom ist eine sehr seltene Form eines Nierenzellkarzinoms, die von den Sammelrohren ( lateinisch Tubulus renalis colligens, Ductus Bellini) ausgeht. Previously, due to its location, CDC was commonly diagnosed as renal cell carcinoma or a subtype of renal cell carcinoma. This tumour often occurs in a young population and has a bad prognosis. Bellini duct carcinoma: two case reports. Albadine R, Schultz L, Illei P, Ertoy D, Hicks J, Sharma R, Epstein JI, Netto GJ. Elwood H, Chaux A, Schultz L, Illei PB, Baydar DE, Billis A, Sharma R, Argani P, Epstein JI, Netto GJ. Atypical tumor cells form ribbons, tubules or nests, penetrate the basement membrane of the duct and infiltrate the surrounding tissue (fat tissue - Photo, skeletal muscle and/or skin), lymphatics, … Author information: (1)Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. Invasive (infiltrating) carcinoma, NST (No Specific Type) of the breast is a malignant epithelial tumor resulted from proliferation of ductal epithelium of breast. Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma: clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationship. 2011 Aug;78(2):474.e1-5. Printed from Surgical Pathology Criteria: Carcinoma of the collecting ducts of Bellini, Collecting duct carcinoma should be considered a diagnosis of exclusion, Frequently extends into renal cortex and/or pelvis, Usually single layer of cuboidal lining cells with hobnail nuclei, Cytoiplasm usually pale eosinophilic to clear, Defined by presence of a distinct spindle cell component occupying at least one microscopic low-power field (×40), Frequent mixed acute and chronic inflammation, Nuclei lare, vesicular and highly pleomorphic with prominent nucleoli, Dysplastic epithelial lining frequently seen in adjacent collecting duct, Edge of tumor poorly defined with infiltration of adjacent kidney, Extra-renal and vascular invasion frequent, Cases described as low grade collecting duct carcinomas in the past are better classified as one of the following, Considered by some reports to be a variant of collecting duct carcinoma, Overlaps histopathologically with collecting duct carcinoma but is separated based on the following features, Lack of INI1 expression (Cheng 2008) vs retention in 85% of collecting duct carcinoma (Elwood 2011), If multiple, metastsis should be strongly considered, Both may show predominantly papillary architecture, HLRCC-associated RCC more likely to resemble Type 2 PRCC with larger tumor cells, often with higher nuclear grade and eosinophilic cytoplasm, Definitionally high grade (Fuhrman grade 3 or 4)i, Grade should be assigned based on the siingle high power field showing the greatest degre of nuclear pleomorphism, WHO/ISUP grading system for clear cell and papillary renal cell carcinomas, Cases described as low grade collecting duct carcinomas are better classified as one of the following, 20-40% have distant metastases at presentation, One report that found same behavior in usual RCC when matched for grade and stage (Karakiewicz). -->, Prominent eosinophilic nucleoli Collecting duct carcinoma, also known as Bellini duct carcinoma is a rare renal tumour of high malignancy. Human epithelial cells of the kidney present a wide spectrum of cytological and histological variation. It was previously subgrouped with the RCCs by the World Health Organization (WHO) in 1981 with the alternative name "Bellini duct carcinoma," but has since been recognized as a separate entity. Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma are rare aggressive neoplasms of putative distal nephron origin. Das Ductus-Bellini-Karzinom ist eine sehr seltene Form eines Nierenzellkarzinoms, die von den Sammelrohren (lateinisch Tubulus renalis colligens, Ductus Bellini) ausgeht. On T2 weighted images, tumors are hyperintense compared with contralateral parotid. Robert V Rouse MD emailE=('john.higgins' + '@' + 'stan' + 'ford.edu') Grade 1. Clinico-pathological findings are similar to both conventional renal cell carcinoma and transitional cell carcinoma. Less commonly associated with invasive carcinoma. Cystic hypersecretory duct carcinoma is morphologically distinguishable from juvenile (secretory) carcinoma and from mucinous (colloid) carcinoma. (range 30 to 150). First described in 1949, case reports and review articles constitute a major source of information on collecting duct carcinoma, whereas Davis and colleagues and the pediatric tumor registry have contributed the seminal works on renal medullary carcinoma. Bellini duct carcinoma of kidney derives from collecting duct and is associated with an aggressive course and extremely poor prognosis. Invasive ductal carcinoma of the breast, also breast invasive ductal carcinoma, is the most common form of invasive breast cancer.It may arise from ductal carcinoma in situ.. Tumors of the Kidney, Bladder and Related Urinary Structures, Atlas of Tumor Pathology, AFIP Fourth Series, Fascicle 1, 2004. Tokuda N, Naito S, Matsuzaki O, et al. Lectin histochemistry demonstrated positive staining with soyabean agglutinin and peanut agglutinin. PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. We report the case of a 62-year old … Collecting duct carcinoma is an aggressive malignancy derived from the renal medulla, whereas most renal cell carcinomas arise from the convoluted tubules of the cortex [1,2,3,4]. 2010 Jul;34(7):965-9. Essentially every case associated with sickle cell trait or sickle cell disease .style1 {font-family: Arial, Helvetica, sans-serif} Nucleoli are conspicuous and eosinophilic at 400x and visible but not prominent at 100x. J Urol. Karakiewicz PI, Trinh QD, Rioux-Leclercq N, de la Taille A, Novara G, Tostain J, Cindolo L, Ficarra V, Artibani W, Schips L, Zigeuner R, Mulders PF, Lechevallier E, Coulange C, Valeri A, Descotes JL, Rambeaud JJ, Abbou CC, Lang H, Jacqmin D, Mejean A, Patard JJ. Carcinoma. Collecting duct carcinoma (CDC) with a mass of coagulative necrosis is very rare. Conclusions: Bellini duct carcinoma is known as a highly aggressive renal tumor. Mod Pathol 21 (7): 807-16. doi : 10.1038/modpathol.2008.65 . Collecting duct carcinoma, also known as Bellini duct carcinoma is a rare renal tumour of high malignancy. It was detected clinically but never because of macroscopic hematuria. In the older pathology literature, collecting duct carcinoma was sometimes referred to as Bellini duct carcinoma, reflecting its presumed site of origin. [1][2], Abzugrenzen sind Urothelkarzinome des oberen Harntraktes und papilläre Nierenzellkarzinome. Urology. Stage was pT3, pT2 and pT1 in 7, 1 and 2 cases, respectively. Author information: (1)Department of Urology, Clínica Plató, Barcelona, Spain. Neoplastic includes: ADH and LDH. A 69 years old patient, enters in our department with symptoms of massive hematuria. Bellini duct tumor is an unusual variant of renal cell carcinoma which has received some attention in the recent literature. emailE=('rouse' + '@' + 'stan' + 'ford.edu') Mod Pathol. IARC Press: Lyon 2016. It is the most common type of breast cancer (70 - 80 %). Tokuda N, Naito S, Matsuzaki O, Nagashima Y, Ozono S, Igarashi T; Japanese Society of Renal Cancer. Author information: (1)Department of Urology, Clínica Plató, Barcelona, Spain. 2008 Sep;39(9):1350-9. Collecting duct carcinoma (CDC) of the kidney, also known as Bellini tumor, is a rare kidney neoplasm, accounting for about 1–2% of the total of epithelial kidney tumors. Characterization of Clinical Cases of Collecting Duct Carcinoma of the Kidney Assessed by Comprehensive Genomic Profiling. Branch duct type. S. Wolter, A. Heidenreich, B. Krug, U. Engelmann: C. G. Hammerschmied, B. Walter, A. Hartmann: N. Tokuda, S. Naito, O. Matsuzaki, Y. Nagashima, S. Ozono, T. Igarashi: M. Parr: Immunhistochemische Untersuchung des Ductus Bellini-Karzinoms zur Abgrenzung von Urothel-karzinomen des oberen Harntrakts und papillären Nierenzellkarzinomen. It is rare, accounting for 1-3% of all kidney cancers. Orsola A(1), Trias I, Raventós CX, Español I, Cecchini L, Orsola I. Collecting (Bellini) duct carcinoma (CDC) or Bellini duct carcinoma (BDC) is a rare subtype of kidney tumors, accounting for less than 3% and known to have the worst prognosis. http://surgpathcriteria.stanford.edu/, Kurt Schaberg MD BDC comprises <1% of all renal tumors , but it is extremely aggressive and is accompanied by metastatic diseases in the majority of reported cases. We report our 12-year experience with CDC and the results of a retrospective analysis of patients and tumor characteristics, clinical manifestations, and imaging features by computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET)/CT. Here we present a rare case of BDC supported by the results of lectin histochemistry studies. We report the case of a 62-year old … Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the duct of Bellini of the kidney and also known by several synonyms like Bellini duct carcinoma, medullary renal carcinoma, distal renal tubular carcinoma and distal nephron carcinoma[1, 2].CDC is an unusual variant of renal cell carcinoma and accounts for about 1% of all renal cell carcinomas. Das männliche Geschlecht ist etwa doppelt so häufig betroffen. Histomorphological differentiation from the more common renal cell carcinoma of the proximal tubuli is difficult. emailE=('kschaber' + '@' + 'stan' + 'ford.edu') 2012 Sep;36(9):1265-78. Unlike renal cell carcinoma 1, (RCC), CDC arises from the renal medulla of Bellini Eur Urol. Collecting duct carcinoma is an aggressive malignancy derived from the renal medulla, whereas most renal cell carcinomas arise from the convoluted tubules of the cortex [1,2,3,4]. Srigley JR, Delahunt B. Frequently extends into renal cortex and/or pelvis; Predominantly tubular pattern Gland-forming Urothelial Carcinoma Collecting Duct Carcinoma; Adjacent usual urothelial carcinoma or carcinoma in situ frequently present: Lacks urothelial components: May show areas of squamous differentiation: No squamous differentiation: CK20+, p63+, PAX8 infrequent: CK20-, p63 14%, PAX8+ Breast Carcinomas. Quel que soit l'examen radiologique, la présence d'une volumineuse tumeur rénale unique et infiltrante doit de toute façon faire systématiquement évoquer le diagnostic à l'urologue . Bellini duct carcinoma; Carcinoma of the collecting ducts of Bellini; Diagnostic Criteria. Orsola A(1), Trias I, Raventós CX, Español I, Cecchini L, Orsola I. As a result, it is hardly surprising that there are no references to renal cell carcinoma (RCC) combined with CDC of the same kidney in the literature. the stroma looks too cellular. Grade 2. Although renal carcinoma can involve any type of renal cell, the most common is renal cell carcinoma of the proximal tubuli. Materials and methods: Ten patients underwent surgery, including radical nephrectomy in 9 and partial nephrectomy in 1, for collecting duct carcinoma diagnosed by histological and immunohistochemical criteria. 1998 Feb;15(1):54-67. Bellini Duct Carcinoma (BDC) or collecting duct carcinoma is a rare but very aggressive renal neoplasm which originates from the epithelium of the ducts of Bellini in the distal tubule. Department of Pathology Mod Pathol. Here, we report an interesting case of Collecting Duct Carcinoma (CDC) with Inferior Vena Cava (IVC) thrombus and large retroperitoneal lymph nodes and diffuse desmoplastic reaction. Background Collecting (Bellini) duct carcinoma (CDC) is a highly malignant and rare kidney tumor. //--> with a clear perinucleolar halo, High grade renal adenocarcinoma arising in medulla of the kidney, with a predominantly invasive tubular growth pattern, Clearly overlaps morphologically and immunophenotypically with, Metastatic adenocarcinoma must be ruled out in every case, Mucinous tubular and spindle cell carcinoma, Mucinous tubular and spindle cell carcinoma, Mucinous Tubular and Spindle Cell Carcinoma of the Kidney, Clear cell (conventional) renal cell carcinoma, Multilocular renal cell neoplasm of low malignant potential, Hereditary leiomyomatosis associated renal cell carcinoma, Neuroblastoma associated renal cell carcinoma, Renal cell carcinoma associated with end stage renal disease, Succinate dehydrogenase-deficient renal cell carcinoma, Thyroid-like follicular carcinoma of the kidney, Clear cell papillary renal cell carcinoma, Oncocytic papillary renal cell carcinoma, CD10, AMACR/Racemase, PN15/gp200 positive, CD10, AMACR/Racemase, PN15/gp200 negative, Adjacent usual urothelial carcinoma or carcinoma in situ frequently present, May show areas of squamous differentiation, Associated with sickle cell trait/disease, Prominent invasion and desmoplastic stroma, Nucleoli are absent or inconspicuous and basophilic at 400x magnification, Nucleoli are conspicuous and eosinophilic at 400x and visible but not prominent at 100x, Nucleoli are conspicuous and eosinophilic at 100x, Extreme nuclear pleomorphism, multinucleate giant cells, and/or rhabdoid and/or sarcomatoid differentiation. 2008 Jun;21(6):647-52. Pathology and genetics of tumors of the Urinary System and Male Genital Organs, 4th edition,. Bislang wurde über mehrere Hundert Betroffene berichtet, das Alter bei Erkrankung reichte von 13 bis 38 Jahren. rare renal tumors – bellini duct carcinoma andrzej kierstan 1 , Marek sosnowski 1 , radosław Minias 2 , Zbigniew Jabłonowski 1 1 1 st Department of Urology, Medical University of Łódź, Poland Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma: clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationship. Moch H, Humphrey PA, Ulbright TM, Reuter VE eds. In addition, immunohistological and electronmicroscopical results support the origin of these tumours from the renal collecting ducts, especially the papillary ducts (Bellini … Surgical Pathology Criteria The patient underwent left open radical nephrectomy with IVC thrombectomy … Collecting duct carcinomas (CDCs) are highly aggressive tumors with poor survival at 1 year and are often metastatic at the time of diagnosis. Bellini duct carcinoma: a case report. Main duct type. We hypothesized that these distinct tumor types may share a common origin. Grade 4. Natsume O(1), Ozono S, Futami T, Ohta M. Author information: (1)Department of Urology, Nara National Hospital, Japan. Stanford University School of Medicine The coexistence of two synchronous neoplasms in the same kidney is highly infrequent. document.write('' + emailE + '') Invasive (infiltrating) carcinoma, NST (No Specific Type) of the breast is a malignant epithelial tumor resulted from proliferation of ductal epithelium of breast. In the older pathology literature, collecting duct carcinoma was sometimes referred to as Bellini duct carcinoma, reflecting its presumed site of origin. Jabbour R, Maddah J, Makhoul R, Mokbel E, Nasr F. We report two rare cases of Bellini duct carcinoma, a rare variant of renal cell carcinoma.CASE 1: The patient, a 73-year-old female, was admitted to the hospital for macroscopic hematuria and right flank pain. Borderline mucinous tumour. "Extrahepatic bile duct carcinoma with extensive intraepithelial spread: a clinicopathological study of 21 cases.". Longer follow-up and study of additional cases will be necessary to determine if this lesion has distinctive clinical characteristics. Oueslati A, Saadi A, Chakroun M, Zaghbib S, Blel A, Ksentini M, Bouzouita A, Derouiche A, Ben Slama MR, Rammeh S, Ayed H, Chebil M. Int J Surg Case Rep, 76:195-198, 28 Sep 2020 Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the papillary duct of the kidney. It is known to originate in the distal part of the collecting duct (1), and has a very dismal prognosis, with short survival and … Urology 2005; 65:49. 2009 Jun;22 Suppl 2:S2-S23. Though generally symptomatic, the aggressive nature of most of these tumours is such that more than 50% of patients have metastatic disease at the time of initial diagnosis. the stroma looks too cellular. Collecting (Bellini) duct carcinoma (CDC) or Bellini duct carcinoma (BDC) is a rare subtype of kidney tumors, accounting for less than 3% and known to have the worst prognosis. 2006 Jul;176(1):40-3. [1] Although some cases had been reported earlier, [2] it was not recognized as a distinct clinicopathologic entity until 1986 when Lewi and Fleming [3] determined the Lobular carcinoma (a pitfall) may appear to be a stromal problem, i.e. Uncommon and recently described renal carcinomas. Gupta R, Billis A, Shah RB, Moch H, Osunkoya AO, Jochum W, Hes O, Bacchi CE, de Castro MG, Hansel DE, Zhou M, Vankalakunti M, Salles PG, Cabrera RA, Gown AM, Amin MB. Notes: Borderline tumours are rare. Mod Pathol 21 (7): 807-16. doi : 10.1038/modpathol.2008.65 . Collecting duct renal cell carcinoma: a matched analysis of 41 cases. Due to early metastatic spread and insufficient therapeutic options, it has a very dismal prognosis. Mean tumor size was 94 mm.